Scientists from the University of Newcastle in the UK have found that the activity of a key metabolic enzyme, mitochondrial complex II, found in human skin cells, decreases with age. The researchers hope their discovery will help develop effective anti-aging treatments.
The study is published in the Journal of Investigative Dermatology. It is briefly reported by the Medicalxpress portal. British scientists have found that the activity of the mitochondrial complex II is significantly reduced in old skin. The activity of this enzyme was measured by the authors of the work in 27 volunteers aged 6 to 72 years. Samples were taken from areas of the skin protected from the sun.
“With age, the bioenergy in our cells decreases, while the content of harmful free radicals increases. This process is easy to see on our skin, where wrinkles and sagging appear with age, ”says one of the authors of the work, Professor of Molecular Dermatology at Newcastle University Mark Burch-Machin.
According to him, a key metabolic enzyme - the mitochondrial complex II - is a hinge between two important ways of creating energy in cells. A decrease in its activity contributes to a decrease in bioenergy in aging skin.
Thanks to this research, scientists have developed a specific biomarker for the development of anti-aging treatments and beauty products that can counteract the decrease in bioenergy in skin cells.