Most expensive substances in the world in ascending order
Antimatter is known as the most expensive substance on earth, estimated at $ 25 billion per milligram of positrons , or $ 62.5 trillion per gram of antihydrogen.  According to CERN, it cost several hundred million Swiss francs to produce a billionth of a gram of antimatter (the volume used in particle-antiparticle collisions).
When matter and antimatter interact, their mass is converted into energy. This reaction is called annihilation. Antimatter is the leader among the known substances in terms of energy density.
It is estimated that when 1 kg of antimatter and 1 kg of matter enter into interaction, approximately 1.8 × 1017 joules of energy will be released, which is equivalent to the energy released in an explosion of 42.96 megatons of TNT. The most powerful nuclear device ever exploded on the planet, Tsar Bomba (weight ~ 20 tons), corresponded to 57 megatons. It should be noted that about 50% of the energy released during annihilation (the reaction of a nucleon-antinucleon pair) is released in the form of neutrinos, which practically do not interact with matter.