Why is the hangover so tormented?

The production and drinking of alcoholic beverages has been practiced by mankind for a long time. We drink alcohol when we feel good or, on the contrary, very bad, alcohol makes people more liberated, relieves stress, allows us to untie tongues even in an unfamiliar company and have a good time. But, as they say, the better in the evening, the worse in the morning. The torment begins when the decay products of alcohol begin to poison the body. Whatever you do, everything is useless - for several hours your body is doomed to go through a painful, exhausting process popularly called a hangover. Let's see why a hangover causes such torment.

1. Hangovers make you urinate frequently (that is, dehydration) by blocking the release of vasopressin, an antidiuretic hormone produced in the posterior pituitary gland, which allows the kidneys to absorb water. Without vasopressin, fluid flows directly into the bladder.

2. Hangovers cause headache and nausea

When you go to the toilet too often, the body is deprived of calcium and magnesium, hence the person becomes nervous and irritable and has a headache. ...

3. Hangovers keep you awake

As the concentration of alcohol in your blood rises, your body becomes agitated, so you suddenly wake up or cannot fall asleep deeply. It becomes difficult to concentrate and memorize. This is because the withdrawal of alcohol creates an inflammatory response in the immune system.

4. Hangovers cause stress

The interaction between the brain, pituitary gland, and adrenal glands (hypothalamic-pituitary-adrenal axis) helps regulate the body's response to stress. The adrenal cortex hormone cortisol plays a key role in reducing stress levels as it affects many systems in the body. However, if there is too much cortisol, the body's ability to deal with stress is reduced.

5. Hangovers make you more susceptible to colds and other illnesses

During a hangover, the body is unable to withstand certain biological stressors. Fortunately, this only lasts about 24 hours.

6. You feel tired

This is due to the fact that the liver begins to break down glycogen, converting it into glucose, which is excreted from your body along with urine. This glycogen should energize you.

7. Heartburn and vomiting may begin

Alcohol increases the level of acidity in the stomach, and therefore its contents can be pulled out. With an excess of alcohol in the blood, the enzyme systems cannot cope with the complete conversion of acetaldehyde into acetic acid; as a result, an intermediate product, acetaldehyde, accumulates, which is more toxic than alcohol. Acetaldehyde (ethanal) is 10-30 times more toxic than alcohol itself. In addition, alcohol causes the formation of the enzyme CYP2E1, which itself can form toxins and free radicals, the presence of toxic substances leads to vomiting.

8. Hangovers can make you shiver

Disruption of neurological balance is caused by the cessation of the flow of alcohol into the body. The tremors can range from mild tremors to seizures. You feel confused and disoriented.

9. Hangovers can even cause hallucinations.

This phenomenon is known as delirium tremens and occurs when the autonomic nervous system becomes overactive. Women experience these conditions less often than men.